Background:

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Alternative splicing results in multiple transcript variants.

Applications:

ELISA, IHC

Name of antibody:

MAP2K7

Immunogen:

Synthetic peptide of human MAP2K7

Full name:

mitogen-activated protein kinase kinase 7

Synonyms:

MEK; MKK7; JNKK2; MEK 7; MAPKK7; PRKMK7; SAPKK4; SAPKK-4

SwissProt:

O14733

ELISA Recommended dilution:

5000-10000

IHC positive control:

Human liver cancer and human prostate cancer

IHC Recommend dilution:

25-100